If you condensed your most recent meal down to a few pills, would they be tiny dynamos, or the nutritional equivalent of Tic Tacs? If you’re like most men, what’s on your plate falls somewhere in between—that is, leaving plenty of room for improvement. “If men start to favor certain foods—meat and potatoes, for example—they may develop nutritional blind spots as a result,” says Kristie Lancaster, Ph.D., an associate professor of nutrition at New York University.

This can be a problem, because your body needs a basic roster of vitamins and minerals to run properly. If your regular diet comes up short, you may need a multivitamin to reach this nutritional baseline. But to actually boost your health, you need to consider moving beyond a multi by folding in some less common elements. Lycopene, for instance, is a powerful antioxidant found in tomatoes. Red yeast rice, a heart-healthy statin. Bottled boosters such as these can be insurance policies for your nutritional blind spots—and if you have specific health concerns, a form of extended coverage

The right supplements can help your heart, sharpen your immune system, and even improve your sex life. The wrong ones, however, can be ineffective or even harmful. “You run into problems because most men are ‘prescribing’ these things themselves,” says Tod Cooperman, M.D., president of consumerlab.com, an independent tester of health and nutritional products. “Don’t take supplements with abandon. They should be used carefully, because taking in too much of certain nutrients can cause problems.”

We consulted with top doctors, reviewed the latest research, and waded through marketers’ claims to bring you 18 of the best supplements for men. Use our guide—along with advice from your own doc, since many supplements can interact with other medications—to fine-tune your strategy.

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